Bulletin Of The World Health Organization
The volume of blood samples in the study of children's health: a review of safe doses
Stephen RC Howie
Goal
Determine the maximum allowable dose of blood collection in pediatrics, corresponding to the "physiological minimum risk."
Methods
A review of the literature to find data concerning the negative effects of taking blood samples from children, as well as recommendations on the amount of samples in pediatric research. Search covered Medline, EMBASE, other sources on the Internet and the Internet, as well as a bibliography listed in the identified sources. Was also carried out consulting with experts Health.Producrate.Com
Findings
Five studies were identified and nine recommendations. Current recommendations define the maximum tolerated dose in pediatric blood collection ranges from 1-5% of total blood volume (COS) for 24 hours to 10% COS for eight weeks. Available data are limited, and include the results of non-randomized studies showing a minimal risk of a single blood sample dose to 5% DCS.
Output
Available experience is consistent with the finding that all of the identified recommendations are consistent with the framework of "minimal risk". However, in order to draw more definitive conclusions needed more and better data quality.
Researchers and institutional review boards should consider dose blood samples for clinical and research purposes in the amount, rather than individually. Must take into account the overall health of the child and to take special care in case of illness, which can deplete the amount of blood or hemoglobin or hinder its replenishment. It is also imperative measures in place governing the appropriateness and validity of the local conditions and procedures for blood sampling combined doses.
Stephen RC Howie
Goal
Determine the maximum allowable dose of blood collection in pediatrics, corresponding to the "physiological minimum risk."
Methods
A review of the literature to find data concerning the negative effects of taking blood samples from children, as well as recommendations on the amount of samples in pediatric research. Search covered Medline, EMBASE, other sources on the Internet and the Internet, as well as a bibliography listed in the identified sources. Was also carried out consulting with experts Health.Producrate.Com
Findings
Five studies were identified and nine recommendations. Current recommendations define the maximum tolerated dose in pediatric blood collection ranges from 1-5% of total blood volume (COS) for 24 hours to 10% COS for eight weeks. Available data are limited, and include the results of non-randomized studies showing a minimal risk of a single blood sample dose to 5% DCS.
Output
Available experience is consistent with the finding that all of the identified recommendations are consistent with the framework of "minimal risk". However, in order to draw more definitive conclusions needed more and better data quality.
Researchers and institutional review boards should consider dose blood samples for clinical and research purposes in the amount, rather than individually. Must take into account the overall health of the child and to take special care in case of illness, which can deplete the amount of blood or hemoglobin or hinder its replenishment. It is also imperative measures in place governing the appropriateness and validity of the local conditions and procedures for blood sampling combined doses.